{"id":18597,"date":"2025-12-12T12:11:50","date_gmt":"2025-12-12T10:11:50","guid":{"rendered":"https:\/\/trialoog.taltech.ee\/miks-uhed-lihased-vasivad-kiiremini-kui-teised\/"},"modified":"2025-12-18T12:21:05","modified_gmt":"2025-12-18T10:21:05","slug":"miks-uhed-lihased-vasivad-kiiremini-kui-teised","status":"publish","type":"post","link":"https:\/\/trialoog.taltech.ee\/en\/miks-uhed-lihased-vasivad-kiiremini-kui-teised\/","title":{"rendered":"The real reason some muscles never tire"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>At TalTech\u2019s School of Science conference, early stage researcher K\u00e4rol Soodla from the Department of Cybernetics explained something most of us never think about: why some muscles get tired quickly, while others can hold us upright all day long.<\/p>\n","protected":false},"author":8,"featured_media":18365,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[251],"tags":[783,563,782,763,766,562],"class_list":["post-18597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-cybernetics","tag-health-technology","tag-kuberneetika-instituut","tag-loodusteaduskond","tag-school-of-science","tag-tervisetehnoloogia-en"],"acf":{"postbuilder":[{"acf_fc_layout":"text","type":"text","text":"She started with the basics. Our body has two main muscle types. \u201cWe have glycolytic muscles that produce a lot of strength \u2013 for example, when sprinting \u2013 and we have oxidative muscles that help us maintain posture,\u201d <a href=\"https:\/\/www.etis.ee\/CV\/K%C3%A4rol_Soodla\" target=\"_blank\" rel=\"noopener\">Soodla<\/a> said. Glycolytic muscles are built for short bursts and don\u2019t have much room for mitochondria \u2013 the tiny \u201cpower plants\u201d of the cell. Oxidative muscles are the opposite: they\u2019re full of mitochondria and made for slow, steady work.\r\n\r\n[caption id=\"attachment_18401\" align=\"alignright\" width=\"394\"]<img class=\" wp-image-18401\" src=\"https:\/\/trialoog.taltech.ee\/wp-content\/uploads\/2025\/12\/Soodla-257x320.jpeg\" alt=\"K\u00e4rol Sodla\" width=\"394\" height=\"490\" \/> K\u00e4rol Sodla[\/caption]\r\n\r\nThis difference makes one enzyme especially important: AMPK, the cell\u2019s built-in energy sensor. When a muscle starts running low on fuel, AMPK tells the cell to pull in more nutrients so it can keep working. \u201cIf AMPK is activated, it signals the translocation of substrate transporters to the cell membrane, so we can take more substrate into the cell,\u201d Soodla explained.\r\n\r\nHere\u2019s where it gets interesting. <a href=\"https:\/\/taltech.ee\/en\/contacts\/laboratory-systems-biology\" target=\"_blank\" rel=\"noopener\">Soodla\u2019s team<\/a> found that the two muscle types have different level of AMPK activation. That was unexpected, because muscles overall aren\u2019t low on fuel, when we just use them for daily activity.\r\n\r\nThe researchers think that energy levels are not the same throughout the cells. Soodla explained that cells maintain several distinct AMPK pools \u2013 in the mitochondria, nucleus, lysosomes and around the myofibrils \u2013 and each of these can switch on separately. Therefore, Soodla\u2019s team is now shifting their focus on AMPK\u2019s location inside the cells to study which pools of AMPK are more activated in postural muscles.\r\n\r\nAlthough, they don\u2019t know exactly how AMPK is more activated in postural muscles, the finding makes sense: muscles that are always active have higher AMPK activation, because their continuous work demands more access to fuel.\r\n\r\nTa alustas p\u00f5hiasjadest. Meie kehas on kaks peamist lihaset\u00fc\u00fcpi. \u201eOn gl\u00fckol\u00fc\u00fctilised lihased, mis toodavad palju j\u00f5udu \u2013 n\u00e4iteks sprindis \u2013, ning oks\u00fcdatiivsed lihased, mis aitavad meil r\u00fchti hoida,\u201d s\u00f5nas <a href=\"https:\/\/www.etis.ee\/CV\/K%C3%A4rol_Soodla\" target=\"_blank\" rel=\"noopener\">Soodla<\/a>. Gl\u00fckol\u00fc\u00fctilised lihased on m\u00f5eldud l\u00fchiajalisteks ja intensiivseteks pingutusteks ning neis pole eriti ruumi mitokondritele \u2013 raku pisikestele \u201eelektrijaamadele\u201d. Oks\u00fcdatiivsed, r\u00fchti hoidvad lihased on vastupidised: need on mitokondritest pungil ja kohandunud aeglaseks, \u00fchtlaseks t\u00f6\u00f6ks.","image":null,"align":""}],"related_authors":[{"author":7990,"position":"Trialoogi toimetaja"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.1 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>The real reason some muscles never tire - Trialoog<\/title>\n<meta name=\"description\" content=\"TalTechi konverentsil selgitas K\u00e4rol Soodla, miks \u00fched lihased v\u00e4sivad kiirelt, teised aga hoiavad meid terve p\u00e4eva p\u00fcsti.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trialoog.taltech.ee\/en\/miks-uhed-lihased-vasivad-kiiremini-kui-teised\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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